I've received the report that lines containing GTK_PATH and LIBGLADE_MODULE_PATH in /etc/xdg/xfce4/xinitrc break 32bit applications.

$ grep -n 'GTK_PATH=\|LIBGLADE_MODULE_PATH='  /etc/xdg/xfce4/xinitrc
64:export LIBGLADE_MODULE_PATH="$LIBGLADE_MODULE_PATH:/usr/lib64/libglade/2.0"
71:export GTK_PATH="$GTK_PATH:/usr/lib64/gtk-2.0"

32-bit applications (eg. acroread or vmware workstation) are not able to find themes correctly. This does not happen if the mentioned two lines are removed.

Question: Is it still necessary needed to setup these two variables. The reporter thinks this was needed when /opt/gnome was used, but it is not needed anymore.