Currently, when the Color Profiles dialog is opened, no device is selected. This is frustrating especially in the case you have only one device listed. Please select the first device on the list.
Simon Steinbeiss referenced this bugreport in commit cc608325eb207bc9262e1202b224c89b4b362099 color: Always select first device on startup (Bug #15266) https://git.xfce.org/xfce/xfce4-settings/commit?id=cc608325eb207bc9262e1202b224c89b4b362099
Agreed (and fixed).
Confirm this works.